منابع مشابه
Combinatorial ganglioside biosynthesis.
Ganglioside Structure and Function Sphingolipids are building blocks of eukaryotic cell surfaces (1). They anchor lipid-bound carbohydrates to the plasma membrane and contribute to the epidermal water permeability barrier of the skin. Glycolipid patterns can reach a high degree of complexity that constitutes a paradigm of combinatorial biosynthesis. During combinatorial biosynthesis, a variety ...
متن کاملRegulation of ganglioside biosynthesis in the nervous system.
Ganglioside biosynthesis is strictly regulated by the activities of glycosyltransferases and is necessarily controlled at the levels of gene transcription and posttranslational modification. Cells can switch between expressing simple and complex gangliosides or between different series within these two groups during brain development. The sequential biosynthesis of gangliosides in parallel enzy...
متن کاملCombinatorial polyketide biosynthesis at higher stage
Modular polyketide synthases (PKS) of bacteria provide an amazing molecular assembly line for the biosynthesis of complex polyketides. This biosynthesis system has, since its discovery, attracted the attention of scientists and pharmaceutical companies owing to its combinatorial potential. It has provoked the idea of constructing ‘unnatural’ product libraries containing a myriad of compounds wi...
متن کاملCommentary Combinatorial biosynthesis: Lesson learned from nature
Polyketides produced by bacteria and fungi represent an extremely rich source of biologically active compounds that find wide-ranging applications as antibiotics, immunosuppresants, antitumor agents, and antiparasitic agents. The striking structural diversity of polyketides that gives rise to these wide-ranging applications is dictated both by the polyketide synthase (PKS) responsible for assem...
متن کاملCombinatorial biosynthesis of antitumor indolocarbazole compounds.
Rebeccamycin and staurosporine are natural products with antitumor properties, which belong to the family of indolocarbazole alkaloids. An intense effort currently exists for the generation of indolocarbazole derivatives for the treatment of several diseases, including cancer and neurodegenerative disorders. Here, we report a biological process based on combinatorial biosynthesis for the produc...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.r200001200